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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40823 |
NCGC00029283
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom syndrome protein helicase (BLM) and Fanconi anemia group J protein helicase (FANCJ) with IC 50 values of 12.5 μM and 3.4 μM, respectively. | |||
T10557 | BLM-IN-1 | Others | Others |
BLM-IN-1 is an effective Bloom syndrome protein (BLM) inhibitor (KD: 1.81 μM; IC50: 0.95 μM). It induces DNA damage response, apoptosis and proliferation arrest in cancer cells |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01010 |
BLM Protein, Human, Recombinant (His)
RecQ-like DNA helicase BLM,BLM,RecQ protein-like 3,... |
Human | E. coli |
BLM Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.0 kDa and the accession number is P54132. | |||
TMPH-02550 |
BLM Protein, Mouse, Recombinant (His & Myc)
BLM,Bloom syndrome protein,RecQ-l... |
Mouse | E. coli |
BLM Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 24.7 kDa and the accession number is O88700. |